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30045-16-0

30045-16-0 structure

Name: Dehydrocorydalin
Chemical Name: Dehydrocorydaline
CAS Number: 30045-16-0
Molecular Formula: C₂₂H₂₄NO₄+
Molecular Weight: 366.43000
Catalog: Biochemical Plant extracts
Create Date: 2018-09-07 18:03:34
Modify Date: 2024-01-02 02:18:16
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.

Name	Dehydrocorydaline
Synonyms	dehydrocorydalmine dehydeocorydaline 5,6-Dihydro-2,3,9,10-tetramethoxy-13-methyldibenzo[a,g]quinolizinium 2,3,9,10-Tetramethoxy-13-methyl-5,6-dihydro-isochino[3,2-a]isochinolinylium Dehydrocorydalin 13-Methyl-2,3,9,10-tetramethoxy-5,6-dihydrodibenzo[a,g]quinolizinium 13-methylpalmatine 2,3,9,10-tetramethoxy-13-methyl-5,6-dihydro-isoquino[3,2-a]isoquinolinylium

Description	Dehydrocorydaline (13-Methylpalmatine) is an alkaloid isolated from traditional Chinese herb Corydalis yanhusuo W.T. Wang. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Natural Products >> Alkaloid Research Areas >> Cancer
Target	Bcl-2 Bax Caspase-7 Caspase-8 PARP
In Vitro	Dehydrocorydaline (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline[1]. Dehydrocorydaline (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression[1]. Dehydrocorydaline (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9[1].
In Vivo	Dehydrocorydaline manifests a low acute toxicity with an LD50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection[2].
References	[1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85. [2]. Yin ZY, et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016 Jun 7;6:27129.

Melting Point	170-173℃
Molecular Formula	C₂₂H₂₄NO₄+
Molecular Weight	366.43000
Exact Mass	366.17100
PSA	40.80000
LogP	3.69320
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9868000

CHEMICAL NAME :: Berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-13-meth yl-

CAS REGISTRY NUMBER :: 30045-16-0

BEILSTEIN REFERENCE NO. :: 1556798

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H24-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 84,73,1964

HS Code	2933990090

518-69-4

30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 253, p. 266,270 Archiv der Pharmazie (Weinheim, Germany), , vol. 256, p. 155,185

1600-27-7

64-19-7

518-69-4

30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 256, p. 155,185

7697-37-2

518-69-4

30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 243, p. 181 Journal of the Chemical Society, , vol. 71, p. 663

7732-18-5

518-69-4

30045-16-0

Literature: Journal of the Chemical Society, , vol. 71, p. 663

64-17-5

7553-56-2

518-69-4

30045-16-0

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 234, p. 505

Precursor 7
518-69-4 1600-27-7 64-19-7 7697-37-2
7732-18-5 64-17-5 7553-56-2
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4