122457-31-2

122457-31-2 structure

Name: MeIQx-d3
Chemical Name: 8-methyl-3-(trideuteriomethyl)imidazo[4,5-f]quinoxalin-2-amine
CAS Number: 122457-31-2
Molecular Formula: C₁₁H₈D₃N₅
Molecular Weight: 216.26
Catalog: Chemical reagent Deuterated reagent
Create Date: 2016-11-03 03:00:04
Modify Date: 2024-01-10 16:25:39
MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2].

Name	8-methyl-3-(trideuteriomethyl)imidazo[4,5-f]quinoxalin-2-amine
Synonyms	MeIQx-d3

Description	MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2].
Related Catalog	Research Areas >> Cancer
In Vitro	氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。 MeIQx (0.47 mM；0-120 分钟) 与小鼠血红蛋白共价结合，并被小鼠微粒体激活为代谢物[2]。
In Vivo	MeIQx (2.0-200 mg/kg；腹腔注射) 在雄性 Swiss Webster 小鼠中，以剂量依赖性方式与血红蛋白共价结合[2]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lynch AM, et, al. The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. Carcinogenesis. 1991 Jun;12(6):1067-72.