938069-71-7

938069-71-7 structure

Name: CAY10526
Chemical Name: cay10526
CAS Number: 938069-71-7
Molecular Formula: C₁₂H₇BrO₃S
Molecular Weight: 311.151
Catalog: Signaling Pathways Immunology/Inflammation PGE synthase
Create Date: 2017-12-31 13:36:48
Modify Date: 2024-01-23 16:18:26
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1].

Name	cay10526
Synonyms	4-benzo(b)thiophen-2-yl-3-bromo-5-hydroxy-5H-furan-2-one 4-(1-Benzothiophen-2-yl)-3-bromo-5-hydroxy-2(5H)-furanone 2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy- 4-(1-benzothiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one

Description	CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PGE synthase
References	[1]. Sun-Hee Kim, et al. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016 May;29(3):297-308.