919289-58-0

919289-58-0 structure

Name: Ro 25-6981 hydrochloride
Chemical Name: 4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]ph enol hydrochloride (1:1)
CAS Number: 919289-58-0
Molecular Formula: C₂₂H₃₀ClNO₂
Molecular Weight: 375.93
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2016-03-31 12:52:00
Modify Date: 2024-01-01 19:14:45
Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3].

Name	4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]ph enol hydrochloride (1:1)

Description	Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].
In Vivo	Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3]. Animal Model: 6-OHDA-lesioned rats[1] Dosage: 0.39-12.5 mg/kg Administration: I.p. Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound. Animal Model: Male albino rats of Wistar strain[2] Dosage: 1, 3 mg/kg Administration: I.p. Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.
References	[1]. Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. [2]. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. [3]. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.

Molecular Formula	C₂₂H₃₀ClNO₂
Molecular Weight	375.93
Exact Mass	375.19700
PSA	43.70000
LogP	4.75630

Hazard Codes	Xi

169197-02-8	169274-78-6
1312991-76-6	173792-73-9
161672-76-0	150596-99-9
1314118-94-9	76061-76-2
13549-69-4	1312991-77-7