375345-95-2

375345-95-2 structure

Name: Mibampator
Chemical Name: N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
CAS Number: 375345-95-2
Molecular Formula: C₂₁H₃₀N₂O₄S₂
Molecular Weight: 438.604
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2017-04-15 11:00:51
Modify Date: 2024-01-14 19:14:34
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

Name	N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
Synonyms	Mibampator 2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]- UNII-A9V5BW73UU N-[(2R)-2-(4'-{2-[(Methylsulfonyl)amino]ethyl}-4-biphenylyl)propyl]-2-propanesulfonamide 2-propanesulfonamide LY451395

Description	Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	AMPA receptor[1].
In Vivo	Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].
References	[1]. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31. [2]. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

Density	1.2±0.1 g/cm3
Boiling Point	609.4±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₀N₂O₄S₂
Molecular Weight	438.604
Flash Point	322.4±34.3 °C
Exact Mass	438.164703
PSA	109.10000
LogP	3.25
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.562
Storage condition	2-8℃

375345-98-5

375346-00-2

~93%

375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

344462-93-7

375345-98-5

~77%

375345-95-2

7440-05-3

Literature: Arnold, Macklin Brian; Bleisch, Thomas John; Cuff, George William; Ornstein, Paul Leslie; Zimmerman, Dennis Michael Patent: US2003/225163 A1, 2003 ; Location in patent: Page 12-13 ;

375345-98-5

375346-00-2

~99%

375345-95-2

516491-32-0

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

375345-99-6

375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

353235-93-5

375345-95-2

Literature: Miller, William D.; Fray, Andrew H.; Quatroche, John T.; Sturgill, Christa D. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 359 - 364

Precursor 5
375345-98-5 375346-00-2 344462-93-7 375345-99-6
353235-93-5
DownStream 0

56-41-7	108-65-6
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141-78-6	1310-73-2
13463-67-7	1333-86-4