Name | 2,5-diamino-2-(difluoromethyl)pentanoic acid,hydrochloride |
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Synonyms |
Ornithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1)
Eflornithine HCl Monohydrate DFMO HCl 2-(Difluoromethyl)ornithine hydrochloride hydrate dfmo 2-(Difluoromethyl)-DL-ornithine Monohydrochloride Monohydrate MFCD00274036 EINECS 269-532-0 EflornithineHcl Eflornithine (hydrochloride) 2-(Difluoromethyl)-DL-ornithine monohydrochloride DFMO hydrochloride hydrate Eflornithine hydrochloride hydrate MDL 71782 A Vaniqa |
Description | Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women. |
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Related Catalog | |
In Vivo | Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4]. |
Animal Admin | Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3]. |
References |
[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. |
Boiling Point | 347ºC at 760 mmHg |
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Melting Point | 181-184°C |
Molecular Formula | C6H13ClF2N2O2 |
Molecular Weight | 236.645 |
Flash Point | 163.7ºC |
Exact Mass | 236.073929 |
PSA | 89.34000 |
LogP | 1.97510 |
Water Solubility | H2O: >10 mg/mL, soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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WGK Germany | 3 |
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HS Code | 2922499990 |
HS Code | 2922499990 |
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Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |