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75-45-6

75-45-6 structure
75-45-6 structure

Name Difluorochloromethane
Synonyms difluoromonochloromethane
Chloro(difluoro)methane
CFC-22
MFCD00000821
algofrene 6
f22
chlorodifluoromethane
REFRIGERANT 22
monochloro-difluoromethane
FKW22
HFA22
difluoromethyl chloride
1-chloro-1,1-difluoro-methane
FC 22
Methane, chlorodifluoro-
EINECS 200-871-9
Density 1.3±0.1 g/cm3
Boiling Point -38.1±8.0 °C at 760 mmHg
Melting Point -146°C
Molecular Formula CHClF2
Molecular Weight 86.468
Flash Point -89.4±11.9 °C
Exact Mass 85.973480
LogP 0.98
Vapour Pressure 6292.3±0.0 mmHg at 25°C
Index of Refraction 1.278
Stability Stable.
Water Solubility Slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PA6390000
CHEMICAL NAME :
Methane, chlorodifluoro-
CAS REGISTRY NUMBER :
75-45-6
BEILSTEIN REFERENCE NO. :
1731036
LAST UPDATED :
199712
DATA ITEMS CITED :
44
MOLECULAR FORMULA :
C-H-Cl-F2
MOLECULAR WEIGHT :
86.47
WISWESSER LINE NOTATION :
GYFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>43200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 pph/15M
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1380 mg/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
70 pph
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
30 pph/2H
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2457 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 gm/m3/6H/43W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Behavioral - alteration of classical conditioning
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
50000 ppm/5H
SEX/DURATION :
male 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
5 ppm
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,1,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 3540 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,237,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,237,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,149,1987 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 74,1939,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL-AUSTRIA:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1000 ppm (3540 mg/m3);STEL 1250 ppm JAN 1993 OEL-DENMARK:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL-FRANCE:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-GERMANY:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-JAPAN:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (3500 mg/m3) JAN 1993 OEL-RUSSIA:TWA 1000 ppm;STEL 3000 mg/m3 JAN 1993 OEL-SWEDEN:TWA 500 ppm (1800 mg/m3);STEL 750 ppm (2500 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 500 ppm (1800 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORODIFLUOROMETHANE-air:TWA 1000 ppm;STEL 1250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80048 No. of Facilities: 7420 (estimated) No. of Industries: 76 No. of Occupations: 44 No. of Employees: 56234 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80048 No. of Facilities: 12513 (estimated) No. of Industries: 78 No. of Occupations: 57 No. of Employees: 157080 (estimated) No. of Female Employees: 12185 (estimated)
Hazard Codes F,N
Risk Phrases R40;R59
Safety Phrases S23-S59
RIDADR UN 1018;UN 1973
Hazard Class 2.2
HS Code 2903710000
HS Code 2903710000