2086301-47-3

2086301-47-3 structure

Name: (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
Chemical Name: (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
CAS Number: 2086301-47-3
Molecular Formula: C₃₉H₅₈N₆O₇S
Molecular Weight: 754.98
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-11-03 23:00:31
Modify Date: 2024-01-10 10:50:11
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].

Name	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

Description	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.

Molecular Formula	C₃₉H₅₈N₆O₇S
Molecular Weight	754.98