1227056-84-9

1227056-84-9 structure

Name: Ampreloxetine
Chemical Name: Ampreloxetine
CAS Number: 1227056-84-9
Molecular Formula: C₁₈H₁₈F₃NO
Molecular Weight: 321.337
Create Date: 2020-01-12 12:59:50
Modify Date: 2024-01-06 18:58:02
Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). Other Indication Phase 2 Clinical

Name	Ampreloxetine
Synonyms	Piperidine, 4-[2-[(2,4,6-trifluorophenoxy)methyl]phenyl]- 4-{2-[(2,4,6-Trifluorophenoxy)methyl]phenyl}piperidine Ampreloxetine

Description	Ampreloxetine (TD-9855) is a potent monoamine reuptake inhibitor with pIC50 of 8.0, 8.6 and 6.8 for human NET, SERT, and DAT, respectively; displays an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporter; engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7 ng/mL and 50.8 ng/mL, respectively; TD-9855 is an investigational dual norepinephrine (NE) and serotonin (5-HT) reuptake inhibitor with selectivity for NE over 5-HT (NSRI). Other Indication Phase 2 Clinical
References	References 1. Smith JA, et al. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. View Related Products by Target Monoamine Transporter Other Indication