943764-99-6

943764-99-6 structure

Name: Acebilustat
Chemical Name: acebilustat
CAS Number: 943764-99-6
Molecular Formula: C₂₉H₂₇N₃O₄
Molecular Weight: 481.542
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-09-24 07:38:26
Modify Date: 2024-01-02 16:53:49
Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.

Name	acebilustat
Synonyms	Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]- 4-{[(1S,4S)-5-{4-[4-(1,3-Oxazol-2-yl)phenoxy]benzyl}-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl}benzoic acid acebilustat

Description	Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Acebilustat is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1 trial[1]. Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].
References	[1]. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016 Nov 2 [2]. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin Transl Sci. 2016 Oct 28.