954126-98-8

954126-98-8 structure

Name: Danirixin
Chemical Name: Danirixin
CAS Number: 954126-98-8
Molecular Formula: C₁₉H₂₁ClFN₃O₄S
Molecular Weight: 441.904
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2018-04-29 03:51:51
Modify Date: 2024-01-28 12:30:55
Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

Name	Danirixin
Synonyms	Urea, N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N'-(3-fluoro-2-methylphenyl)- 1-{4-Chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-3-(3-fluoro-2-methylphenyl)urea Danirixin GSK1325756

Description	Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Inflammation/Immunology
Target	CXCL8-CXCR2:12.5 nM (IC50)
In Vitro	Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine[1].
References	[1]. Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist?--in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.