456-12-2

456-12-2 structure

Name: Aegeline
Chemical Name: (E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
CAS Number: 456-12-2
Molecular Formula: C₁₈H₁₉NO₃
Molecular Weight: 297.348
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-06-11 14:16:29
Modify Date: 2024-01-05 16:22:56
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

Name	(E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
Synonyms	UNII:60T59LN3SG Aegelin (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylacrylamide 2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- 2-propenamide

Description	Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Neurological Disease
In Vitro	Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein orBax-expressing cells[1]. Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2].
References	[1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [2]. Nugroho AE, et al. Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells. Pak J Pharm Sci. 2011;24(3):359‐367.

Hazard Codes	Xi
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%