158959-32-1

158959-32-1 structure

Name: SC57666
Chemical Name: 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzenee
CAS Number: 158959-32-1
Molecular Formula: C₁₈H₁₇FO₂S
Molecular Weight: 316.39000
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-04-17 12:02:41
Modify Date: 2024-01-10 15:38:21
SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

Name	1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzenee
Synonyms	1-fluoro-4-(2-(4-methylsulfonylphenyl)-1-cyclopenten-1-yl)benzene SC-57666 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]cyclopenten-1-yl] benzene 1-fluoro-4-(2-(4-(methanesulfonyl)phenyl)cyclopent-1-enyl)benzene 1-(4-methanesulphonylphenyl)-2-(4-fluorophenyl)cyclopentene 1-(2-(4-fluorophenyl)cyclopenten-1-yl)-4-(methylsulfonyl)benzene SC57666

Description	SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-2:26 nM (IC50)
In Vitro	SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM)[2].
In Vivo	SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1].
References	[1]. Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81. [2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.