1105698-15-4

1105698-15-4 structure

Name: Salermide
Chemical Name: N-[3-[(2-oxonaphthalen-1-ylidene)methylamino]phenyl]-2-phenylpropanamide
CAS Number: 1105698-15-4
Molecular Formula: C₂₆H₂₂N₂O₂
Molecular Weight: 394.465
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2017-11-09 18:53:21
Modify Date: 2024-01-02 13:38:41
Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.

Name	N-[3-[(2-oxonaphthalen-1-ylidene)methylamino]phenyl]-2-phenylpropanamide
Synonyms	N-(3-{(E)-[(2-Hydroxy-1-naphthyl)methylene]amino}phenyl)-2-phenylpropanamide Salermide Benzeneacetamide, N-[3-[[(1E)-(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methyl-

Description	Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer
Target	SIRT1 SIRT2
In Vitro	Salermide shows a dose-dependent inhibition that rises to 80% at 90 μM and 25 μM against Sirt1 and Sirt2, respectively. Salermide can prompt tumour-specific cell death in a wide range of human cancer cell lines derived from leukaemia (MOLT4, KG1A, K562), lymphoma (Raji), colon (SW480) and breast (MDA-MB-231). Incubation with 100 μM Salermide alone resulted in an increase of cytosolicactivated caspase 3 and a decrease of mitochondrialcytochrome. Salermide alone can induce apoptosis through both extrinsic and intrinsic pathways. Salermide had several antitumorigenic advantages over the earlier described class III HDAC inhibitors: firstly, it mimics the universal proapoptotic effect on cancer samples exhibited by the classical class I, II and IV HDAC inhibitors, and secondly, its proapoptotic effect is cancer-specific[1].
In Vivo	Salermide is well tolerated by mice at concentrations up to 100 μM. Salermide's mechanism of action in vivo is specifically mediated by Sirt1. Intraperitoneal feeding of Salermide has no apparent toxicity in nude mice[1].
Cell Assay	Cell lines (SW480, MDA-MB-231, MOLT4, KG1A, K562 and Raji) are used in the study. Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μM) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus[1].
Animal Admin	Mice: To assess possible adverse effects of Salermide in vivo. To do this, a group of 10 nude mice are intraperitoneal injected 100 μL of 100 μM of Salermide to over 34 days. Diet consumption, body-weight gain, and postural and behavioural changes are monitored throughout the study[1].
References	[1]. Lara E, et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91.

Density	1.2±0.1 g/cm3
Boiling Point	666.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₂N₂O₂
Molecular Weight	394.465
Flash Point	357.0±30.1 °C
Exact Mass	394.168121
PSA	61.69000
LogP	5.40
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.623
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H412
Precautionary Statements	P273-P280
RIDADR	NONH for all modes of transport

1105698-16-5

708-06-5

~86%

1105698-15-4

Literature: Rotili, Dante; Tarantino, Domenico; Nebbioso, Angela; Paolini, Chantal; Huidobro, Covadonga; Lara, Ester; Mellini, Paolo; Lenoci, Alessia; Pezzi, Riccardo; Botta, Giorgia; Lahtela-Kakkonen, Maija; Poso, Antti; Steinkuehler, Christian; Gallinari, Paola; De Maria, Ruggero; Fraga, Mario; Esteller, Manel; Altucci, Lucia; Mai, Antonello Journal of Medicinal Chemistry, 2012 , vol. 55, # 24 p. 10937 - 10947

492-37-5

108-45-2

1105698-15-4

Precursor 4
1105698-16-5 708-06-5 492-37-5 108-45-2
DownStream 0

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