GL Biochem (Shanghai) Ltd.
China
Product Name: AYPGKF-NH2
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

DC Chemicals Limited
China
Product Name: AY-NH2
Price: $3500.0/1g $950.0/100mg $1800.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: (Ala1)-PAR-4 (1-6) amide (mouse)
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

352017-71-1

352017-71-1 structure

352017-71-1 structure

Name: (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt
Chemical Name: ay-nh2
CAS Number: 352017-71-1
Molecular Formula: C₃₄H₄₈N₈O₇
Molecular Weight: 680.79400
Catalog: Peptides
Create Date: 2017-03-20 07:19:54
Modify Date: 2024-01-02 08:28:39
PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

Name	ay-nh2
Synonyms	Proteinase activated receptor 4 amide,mouse PAR-4 AGONIST AMIDE ALA-TYR-PRO-GLY-LYS-PHE-NH2 AYPGKFAMIDE PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 AYPGKF-NH2 (Ala1)-PAR-4 (1-6) amide (mouse) PAR-4 Agonist Peptide, amide

Description	PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR) Peptides Research Areas >> Inflammation/Immunology
Target	PAR-4[1]
In Vivo	Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].
Animal Admin	Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].
References	[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.

Molecular Formula	C₃₄H₄₈N₈O₇
Molecular Weight	680.79400
Exact Mass	680.36500
PSA	252.07000
LogP	2.30290
Storage condition	2-8℃

Safety Phrases	S22-S24/25