Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2

Names

[ Name ]:
Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2

[Synonym ]:
H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
ninamide
NPFF
PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE
F-8-F-NH2
PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
MFCD00076704
F-8-F-NH2,NPFF,F-8-F-aMide
TC Mps1 12
Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2

Biological Activity

[Description]:

Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Mankus JV, et al. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Med Chem. 2012 Jun;4(9):1085-92.

[2]. Jhamandas JH, et al. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8.

Chemical & Physical Properties

[ Density]:
1.38 g/cm3

[ Molecular Formula ]:
C₅₄H₇₆N₁₄O₁₀

[ Molecular Weight ]:
1081.27

[ Exact Mass ]:
1080.59000

[ PSA ]:
412.10000

[ LogP ]:
4.54270

[ Index of Refraction ]:
1.656

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble to 0.50 mg/ml in water.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

The anti-inflammatory potential of neuropeptide FF in vitro and in vivo.

Peptides 47 , 124-32, (2013)

Neuropeptide FF (NPFF) has many functions in regulating various biological processes. However, little attention has been focused on the anti-inflammatory effect of this peptide. In the present study, ...

Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.

Peptides 30(9) , 1683-8, (2009)

GPR103 is one of the orphan G protein-coupled receptors. Recently, an endogenous ligand for GPR103, 26RFa, was identified. Many 26RFa binding sites have been observed in various nuclei of the brain in...

Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats.

Peptides 31(4) , 683-8, (2010)

Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF(A) and pro-NPFF(B)) and two receptors (NPFF(1) and NPFF(2)). NPFF and NPFF receptor mRNAs have been reported ...

Related Compounds

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