Baicalein-5,6,7-trimethylether

Names

[ CAS No. ]:
973-67-1

[ Name ]:
Baicalein-5,6,7-trimethylether

[Synonym ]:
5,6,7-trimethoxy-2-phenylchromen-4-one
5,6,7-Trimethoxyflavone
5,6,7-trimethoxy-2-phenyl-4H-chromen-4-one
Baicalein-5,6,7-trimethylether
5,6,7-trimethoxy-2-phenyl-4H-1-benzopyran-4-one
Baicalein Trimethyl Ether
5,6,7-Trimethoxy-2-phenyl-chromen-4-on
MFCD00017457
5,6,7-trimethoxy-2-phenyl-chromen-4-one

Biological Activity

[Description]:

5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

[Target]

p38-α MAPK[1]

[References]

[1]. Hassan AHE, et al. Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators. Eur J Med Chem. 2019 Jul 9;180:253-267.

Chemical & Physical Properties

[ Density]:
1.242g/cm3

[ Boiling Point ]:
497.4ºC at 760 mmHg

[ Melting Point ]:
165-167°C

[ Molecular Formula ]:
C₁₈H₁₆O₅

[ Molecular Weight ]:
312.31700

[ Flash Point ]:
221.3ºC

[ Exact Mass ]:
312.10000

[ PSA ]:
57.90000

[ LogP ]:
3.48580

[ Index of Refraction ]:
1.585

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%