H-Gly-Arg-Gly-Asp-Ser-OH

Names

[ Name ]:
H-Gly-Arg-Gly-Asp-Ser-OH

[Synonym ]:
Gly-Arg-Gly-Asp-Ser-OH
GRGDS 1/2ACOH 2H2O
H-GLY-ARG-GLY-ASP-SER-OH
GRGDS
GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE
glycyl-arginyl-glycyl-aspartyl-serine
MFCD00076459
L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl

Biological Activity

[Description]:

Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Peptides

[In Vitro]

Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. GRGDS-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2].

[References]

[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.

[2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.66 g/cm3

[ Molecular Formula ]:
C₁₇H₃₀N₈O₉

[ Molecular Weight ]:
490.46800

[ Exact Mass ]:
490.21400

[ PSA ]:
299.15000

[ Index of Refraction ]:
1.664

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

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