Biotin-PEG11-azide

Names

[ Name ]:
Biotin-PEG11-azide

[Synonym ]:
Carbamic acid, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)carbamate

Biological Activity

[Description]:

Biotin-PEG-azide (MW 1000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs[1]

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1]. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₄N₄O₇

[ Molecular Weight ]:
406.474

[ Exact Mass ]:
406.242737

[ LogP ]:
-0.02

Biotin-PEG11-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds