NS 11021

Names

[ Name ]:
NS 11021

[Synonym ]:
1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]thiourea
NS 11021

Biological Activity

[Description]:

NS 11021 is a potent and specific Ca2-activated big-conductance K＋ Channels (KCa1.1 channels) activator. NS 11021 at concentrations above 0.3 μM activates KCa1.1 in a concentration-dependent manner by parallelshifting the channel activation curves to more negative potentials[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

Ca2＋-activated big-conductance K＋ Channels[1]

[References]

[1]. Bentzen BH，et al. The small molecule NS11021 is a potent and specific activator of Ca2⁺-activated big-conductance K⁺ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44.

Chemical & Physical Properties

[ Density]:
1.798±0.06 g/cm3(20 °C , 760mmHg)

[ Boiling Point ]:
507.5±60.0 °C (760 mmHg)

[ Molecular Formula ]:
C₁₆H₉BrF₆N₆S

[ Molecular Weight ]:
511.24

[ Exact Mass ]:
509.97000

[ PSA ]:
110.61000

[ LogP ]:
5.62170

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds

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