Azido-PEG4-Amine

Names

[ Name ]:
Azido-PEG4-Amine

[Synonym ]:
O-(2-Aminoethyl)-O'-(2-azidoethyl)triethylene Glycol
14-Azido-3,6,9,12-tetraoxatetradecan-1-amine
Azido-PEG4-Amine
O-(2-Aminoethyl)-O’-(2-azidoethyl)triethylene Glycol

Biological Activity

[Description]:

PROTAC Linker 20 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 20 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.10 g/mL

[ Molecular Formula ]:
C₁₀H₂₂N₄O₄

[ Molecular Weight ]:
262.30600

[ Exact Mass ]:
262.16400

[ PSA ]:
112.69000

[ LogP ]:
0.47486

[ Appearance of Characters ]:
liquid

[ Index of Refraction ]:
1.4670 to 1.4710

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
UN 2735 8/PG III

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Related Compounds

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