Indene
Names
[ CAS No. ]:
95-13-6
[ Name ]:
Indene
[Synonym ]:
kannit
L56 BHJ
1H-Indene
(+)-xylitol
newtol
Klinit
Kylit
EINECS 202-393-6
Indene
Meso-X
XYLIT
MFCD00003777
eutrit
XYLITE
Xilite
(1H)-indene
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
181.6±0.0 °C at 760 mmHg
[ Melting Point ]:
−5-−3 °C(lit.)
[ Molecular Formula ]:
C9H8
[ Molecular Weight ]:
116.160
[ Flash Point ]:
58.9±0.0 °C
[ Exact Mass ]:
116.062599
[ LogP ]:
2.91
[ Vapour Pressure ]:
1.2±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.596
[ Stability ]:
Stable, but air and light sensitive; may polymerize upon exposure to light. Typically contains aroung 80 - 100 ppm of p-tert-butylcatechol as inhibitor. Refrigerate. Flammable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NK8225000
- CHEMICAL NAME :
- Indene
- CAS REGISTRY NUMBER :
- 95-13-6
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C9-H8
- MOLECULAR WEIGHT :
- 116.17
- WISWESSER LINE NOTATION :
- L56 BHJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 mg/m3/24H/15W-C
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976 *** REVIEWS *** ACGIH TLV-TWA 48 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (45 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,134,1971 OSHA PEL (Construc):8H TWA 10 ppm (45 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (45 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (48 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (47 mg/m3);STEL 20 ppm (95 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 15 ppm (70 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO INDENE-air:10H TWA 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 39820 No. of Facilities: 3158 (estimated) No. of Industries: 24 No. of Occupations: 42 No. of Employees: 61824 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 39820 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 753 (estimated) No. of Female Employees: 376 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H304
[ Precautionary Statements ]:
P301 + P310-P331
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R10;R65
[ Safety Phrases ]:
S23-S24/25-S62
[ RIDADR ]:
UN 3295 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
NK8225000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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Molecular docking is widely used to predict novel lead compounds for drug discovery. Success depends on the quality of the docking scoring function, among other factors. An imperfect scoring function ...
One pot synthesis of indene through copper(I)-catalyzed three-components coupling and cyclization reaction.Org. Biomol. Chem. 10(18) , 3636-41, (2012)
A new and efficient synthesis of substituted indene has been achieved via copper(I)-catalyzed domino three-component coupling and cyclization reaction in moderate to good yield.