Macimorelin acetate

Names

[ CAS No. ]:
945212-59-9

[ Name ]:
Macimorelin acetate

[Synonym ]:
Macimorelin acetate
UNII-AQZ1003RMG
EP 1572 acetate
AEZS-130
ARD 07 acetate

Biological Activity

[Description]:

Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> GHSR

[Target]

GHSR[1]


[In Vivo]

Macimorelin 醋酸酯 (5mg/kg，每日两次，连续 2 周) 可降低 IHKA 小鼠模型的癫痫发作次数和持续时间[2]。 Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks. Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.

[References]

[1]. Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103(8):3083-3093.  

[2]. An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28(9):3100-3112.  

[3]. Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34:

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34N6O5

[ Molecular Weight ]:
534.60700

[ Exact Mass ]:
534.25900

[ PSA ]:
192.67000

[ LogP ]:
5.15690

Related Compounds