Rhapontigenin 3'-O-glucoside

Names

[ Name ]:
Rhapontigenin 3'-O-glucoside

[Synonym ]:
Rhapontigenin 3'-O-glucoside
5-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-2-methoxyphenyl β-D-glucopyranoside
β-D-Glucopyranoside, 5-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-2-methoxyphenyl
Rhapontigenin 3'-O-glucopyranoside

Biological Activity

[Description]:

Rhapontigenin 3'-O-glucoside is a derivative of Rhapontigenin. Rhapontigenin is a potent inactivator of human P450 1A1 and is a good candidate for a cancer chemopreventive agent[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Rhapontigenin exhibits a potent and selective inhibition of human P450 1A1 with an IC50 of 0.4 μM. Rhapontigenin shows 400-fold selectivity for P450 1A1 over P450 1A2 and 23-fold selectivity for P450 1A1 over P450 1B1[1].

[References]

[1]. Chun YJ, et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):389-93.

Chemical & Physical Properties

[ Density]:
1.5±0.0 g/cm3

[ Boiling Point ]:
711.3±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄O₉

[ Molecular Weight ]:
420.410

[ Flash Point ]:
384.0±0.0 °C

[ Exact Mass ]:
420.142029

[ PSA ]:
149.07000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.711

Precursor & DownStream

Precursor

DownStream

Related Compounds

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