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Acetyl-(Tyr1,D-Phe2)-GRF (1-29) amide

Names

[ CAS No. ]:
93965-89-0

[ Name ]:
Acetyl-(Tyr1,D-Phe2)-GRF (1-29) amide

[Synonym ]:
N-AC-TYR(1)-PHE(2)-SOMATOTROPIN RELEASING HORMONE (1-29)-AMIDE
L-Argininamide, N-acetyl-L-tyrosyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl- L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-
NBI 35965 hydrochloride
N-Acetyl-L-tyrosyl-D-phenylalanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl -L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide
Somatoliberin (human pancreatic islet), N-acetyl-2-D-phenylalanine-29-L-argininamide-30-de-L-glutamine-31-de-L-glutamine-32-deglycine-33-de-L-glutamic acid-34-de-L-serine-35-de-L-asparagine-36-de-L-glutamine-37-de-L-glutamic acid-38-de-L-arginine-39-deglycine-40-de-L-alanine-41-de-L-arginine-42-de-L-alanine-43-de-L-arginine-44-de-L-leucinamide-

Biological Activity

[Description]:

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), a growth hormone releasing factor (GRF) analogue, is a vasoactive intestinal peptide (VIP) antagonist[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

VIP[1]


[In Vitro]

[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) 选择性抑制 VIP 和 GRF 刺激的大鼠胰腺浆膜腺苷酸环化酶活性[1]。 [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) (0.1 pM-10 nM; 3 d) 诱导 C6 细胞的剂量依赖性细胞增殖增加[2]。 Cell Proliferation Assay[2] Cell Line: C6 rat glioblastoma cells Concentration: 0.1 pM-10 nM Incubation Time: 3 days Result: Induced a dose-dependent cell proliferation increase.

[References]

[1]. Waelbroeck M, et al. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9.  

[2]. Dufes C, et al. Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro. J Mol Neurosci. 2003;21(2):91-102.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C157H252N44O43S

[ Molecular Weight ]:
3476.015

[ Exact Mass ]:
3473.860596

[ PSA ]:
1475.28000

[ LogP ]:
-2.20

[ Index of Refraction ]:
1.648


Related Compounds