Resolvin D1 methyl ester

Names

[ Name ]:
Resolvin D1 methyl ester

[Synonym ]:
Resolvin D1 methyl ester
Methyl (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxy-4,9,11,13,15,19-docosahexaenoate
RvD1-ME
4,9,11,13,15,19-Docosahexaenoic acid, 7,8,17-trihydroxy-, methyl ester, (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-

Biological Activity

[Description]:

Resolvin D1 methyl ester (RvD1 methyl ester) is the methyl ester of Resolvin D1 (HY-125527). Resolvin D1 methyl ester reduces triglyceride levels[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vivo]

Treating diabetic mice with menhaden oil in the diet or exogenously with resolvins D1 and E1 or the methyl esters of resolvins D1 (1 ng/g ; i.p.; daily) and D2 reduced triglyceride levels to control values or lower in type 2 diabetes C57BL/6J mice[1]. Treating diabetic mice with the methyl esters of resolvins D1 or D2 significantly improved motor nerve conduction velocity compared to non-treated diabetic mice but both motor and sensory nerve conduction velocities in these treated mice remained significantly impaired compared to control mice[1].

[References]

[1]. Alexander Obrosov, et al. Effect of Fish Oil vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy. J Neurol Neurophysiol. 2017;8(6):453.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
562.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₄O₅

[ Molecular Weight ]:
390.513

[ Flash Point ]:
185.4±23.6 °C

[ Exact Mass ]:
390.240631

[ LogP ]:
3.16

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.540

Related Compounds

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