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ARRY-380

Names

[ CAS No. ]:
937265-83-3

[ Name ]:
ARRY-380

[Synonym ]:
HER2-Inhibitor-1
UNII-H32S1659ED
CS-0484
cc-595
Arry-380
ARRY-380 (analog )

Biological Activity

[Description]:

The product is the analog of ARRY-380, ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. ErbB-2 inhibitor ARRY-380


[Related Small Molecules]

Osimertinib (AZD9291) | Tyrphostin B42 (AG-490) | Neratinib (HKI-272) | Genistein | (-)-Epigallocatechin gallate | AG-1478 | Dacomitinib (PF-00299804) | Irbinitinib | Poziotinib | Olmutinib | Sapitinib | AZD-3759 | Pyrotinib | Canertinib dihydrochloride | BMS-690514

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C29H27N7O4S

[ Molecular Weight ]:
569.634

[ Exact Mass ]:
569.184509

[ PSA ]:
144.92000

[ LogP ]:
3.59

[ Index of Refraction ]:
1.709

[ Storage condition ]:
-20℃

Related Compounds

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