H-Arg-Gly-Asp-Val-OH

Names

[ Name ]:
H-Arg-Gly-Asp-Val-OH

[Synonym ]:
Rgdv tetrapeptide
Arg-gly-asp-val
Arginyl-glycyl-aspartyl-valine
L-Arginylglycyl-L-alpha-Aspartyl-L-Valine

Biological Activity

[Description]:

RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

RGDV (25-100 nM; thrombus vessel model) selectively inhibits platelet-dependent thrombus formation and decreases the accumulation of both platelets and fibrin on the collagen substrate in a dose-response manner[1].

[References]

[1]. Cadroy Y, et, al. RGDV peptide selectively inhibits platelet-dependent thrombus formation in vivo. Studies using a baboon model. J Clin Invest. 1989 Sep;84(3):939-44.

[2]. Wang F, et, al. Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif. J Pharm Sci. 2012 Dec;101(12):4559-68.

Chemical & Physical Properties

[ Density]:
1.57g/cm3

[ Boiling Point ]:
821.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₃₁N₇O₇

[ Molecular Weight ]:
445.47100

[ Flash Point ]:
450.4ºC

[ Exact Mass ]:
445.22800

[ PSA ]:
249.82000

[ Index of Refraction ]:
1.644

Related Compounds

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