Lactoferrin

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin has anti-inflammatory, immunomodulatory, and anti-cancer activities[1][2][3].

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

[1]. Pöllänen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16.  

[2]. Berlutti F, et al. Antiviral properties of lactoferrin--a natural immunity molecule. Molecules. 2011 Aug 16;16(8):6992-7018.  

[3]. Cutone A, et al. Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action. Biomolecules. 2020 Mar 15;10(3):456.  

[4]. Marchetti M, et al. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996 Mar;29(2-3):221-31.  

[5]. Varadhachary A, et al. Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Int J Cancer. 2004 Sep 1;111(3):398-403.  

[6]. Han N, et al. Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury. AMB Express. 2019 Oct 31;9(1):177.