AZD-5597

Names

[ Name ]:
AZD-5597

[Synonym ]:
UNII-N7855W19GY
AZD-5597
(S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone

Biological Activity

[Description]:

AZD5597 is an inhibitor of CDK with an IC50 of 2 nM. AZD5597 has potent anti-proliferative effects against a range of cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

IC50: 2 nM (CDK2), 2 nM (CDK1), 39 nM (LoVo)[1]

[References]

[1]. Jones CD, et al.The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₈FN₇O

[ Molecular Weight ]:
437.51

[ Exact Mass ]:
437.23400

[ PSA ]:
87.97000

[ LogP ]:
3.94780

Related Compounds

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