Allopurinol-d2

Names

[ CAS No. ]:
916979-34-5

[ Name ]:
Allopurinol-d2

[Synonym ]:
Allopurinol-d2
Caplenal-d2
Adenock-d2
Allopur-d2
Cellidrin-d2

Biological Activity

[Description]:

Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.

[3]. Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.

Chemical & Physical Properties

[ Density]:
1.92g/cm3

[ Boiling Point ]:
>222°C

[ Molecular Formula ]:
C5H2D2N4O

[ Molecular Weight ]:
138.12

[ Flash Point ]:
234.117°C

[ Exact Mass ]:
138.05100

[ PSA ]:
74.69000

[ LogP ]:
0.05850

Safety Information

[ Hazard Codes ]:
T+

[ RIDADR ]:
2811.0

Related Compounds