NS 9283

Names

[ Name ]:
NS 9283

[Synonym ]:
3-[3-(Pyridin-3-yl)-1,2,4-oxadiazol-5-yl]benzonitrile
NS 9283

Biological Activity

[Description]:

NS9283 is a positive positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors. NS9283 can be used in a series of neurological conditions such as attention deficit hyperactivity disorder (ADHD), schizophrenia, Parkinson's disease and Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[References]

[1]. M Grupe, et al. Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)₃(β2) ₂nicotinic ACh receptors. Br J Pharmacol. 2013 Apr;168(8):2000-10.

Chemical & Physical Properties

[ Density]:
1.37±0.1 g/cm3(20 °C , 760mmHg)

[ Boiling Point ]:
469.9±55.0 °C (760 mmHg)

[ Molecular Formula ]:
C₁₄H₈N₄O

[ Molecular Weight ]:
248.24000

[ Exact Mass ]:
248.07000

[ PSA ]:
75.60000

[ LogP ]:
2.67028

Related Compounds

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