ATB-337

Names

[ Name ]:
ATB-337

[Synonym ]:
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
4-(3-Thioxo-3H-1,2-dithiol-5-yl)phenyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate

Biological Activity

[Description]:

S-Diclofenac is a hybrid molecule of an H2S donor and the NSAID diclofenac. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Wallace JL, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007 Jan;132(1):261-71.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
640.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₅Cl₂NO₂S₃

[ Molecular Weight ]:
504.472

[ Flash Point ]:
341.3±34.3 °C

[ Exact Mass ]:
502.964203

[ PSA ]:
126.90000

[ LogP ]:
7.18

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.756

Related Compounds

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