γ-Glutamyl-S-allylcysteine

γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a naturally occurring organosulfur compound found in garlic. γ-Glutamyl-S-allylcysteine has antiglycative effect and shows radical-scavenging and metal-chelating capacities[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine; 0.1-2.5 mg/mL) inhibits the increase of fluorescence intensity at about 440 nm in a concentration-dependent manner and reduces reacted free lysine side chains[1]. γ-Glutamyl-S-allylcysteine (2.5 mg/mL) prevents Glycation-specific decline in BSA α-helix content and increase in β-sheet in vitro[1]. γ-Glutamyl-S-allylcysteine (2.5 mg/mL) suppresses protein crosslinking to form polymers[1]. γ-Glutamyl-S-allylcysteine (10, 40, 160 μg/mL) shows radical-scavenging and metal-chelating capacities[1].

[1]. Dehong Tan, et al. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.). Nat Prod Res. 2015;29(23):2219-22.

[2]. Yi-Yu Chen, et al. Enzymatic synthesis of γ-L-glutamyl-S-allyl-L-cysteine, a naturally occurring organosulfur compound from garlic, by Bacillus licheniformis γ-glutamyltranspeptidase. Enzyme Microb Technol. Jul-Aug 2015;75-76:18-24.