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8-Epidiosbulbin E acetate

Names

[ CAS No. ]:
91095-48-6

[ Name ]:
8-Epidiosbulbin E acetate

[Synonym ]:
7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,8(1H,4aH)-dione, 6-(acetyloxy)-2-(3-furanyl)octahydro-11b-methyl-, [2S-(2α,4aα,6β,6aα,7α,10α,11aβ,11bα)]- (9CI)

Biological Activity

[Description]:

8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Shriram V, et al. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria. Int J Antimicrob Agents. 2008 Nov;32(5):405-10.

[2]. Lin D, et al. Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. Chem Res Toxicol. 2016 Mar 21;29(3):359-66.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H24O7

[ Molecular Weight ]:
388.42

[ Storage condition ]:
2-8℃

Related Compounds