2-methyl-m-phenylene diisocyanate
Names
[ CAS No. ]:
91-08-7
[ Name ]:
2-methyl-m-phenylene diisocyanate
[Synonym ]:
MFCD00002010
Tolylene 2,6-diisocyanate
2-METHYL-M-PHENYLENE DIISOCYANATE
EINECS 202-039-0
Chemical & Physical Properties
[ Density]:
1.225 g/mL at 25 °C(lit.)
[ Boiling Point ]:
129-133 °C18 mm Hg(lit.)
[ Melting Point ]:
13°C
[ Molecular Formula ]:
C9H6N2O2
[ Molecular Weight ]:
174.15600
[ Flash Point ]:
>230 °F
[ Exact Mass ]:
174.04300
[ PSA ]:
58.86000
[ LogP ]:
1.92960
[ Index of Refraction ]:
n20/D 1.571(lit.)
[ Storage condition ]:
−20°C
[ Stability ]:
Stability Reacts violently with water. Reacts very rapidly with compounds containing an active hydrogen, such as amines, alcohols and acids. Polymerizes rapidly in the presence of base. Combustible. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CZ6310000
- CHEMICAL NAME :
- Benzene, 2,6-diisocyanato-1-methyl-
- CAS REGISTRY NUMBER :
- 91-08-7
- BEILSTEIN REFERENCE NO. :
- 2211546
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C9-H6-N2-O2
- MOLECULAR WEIGHT :
- 174.17
- WISWESSER LINE NOTATION :
- OCNR B1 CNCO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 50 ppb
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 300 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 0.005 ppm (0.035 mg/m3);Carcinogen JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.07 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.005 ppm (0.04 mg/m3);STEL 0.01 ppm JAN 1993 OEL-UNITED KINGDOM:TWA 0.02 mg/m3;STEL 0.07 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0788 No. of Facilities: 609 (estimated) No. of Industries: 14 No. of Occupations: 18 No. of Employees: 15830 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0788 No. of Facilities: 415 (estimated) No. of Industries: 12 No. of Occupations: 22 No. of Employees: 2872 (estimated) No. of Female Employees: 284 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H317-H319-H330-H334-H335-H351-H412
[ Precautionary Statements ]:
P260-P280-P284-P304 + P340 + P310-P342 + P311-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
26-36/37/38-40-42/43-52/53
[ Safety Phrases ]:
S23-S36/37-S45-S61
[ RIDADR ]:
UN 2078 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
CZ6310000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Med. Lav. 103(5) , 361-71, (2012)
Despite its advantages over environmental monitoring, biological monitoring of exposure to 2,4-:2,6-toluene diisocyanate (TDI) mixtures is still underused. The present study was designed in order to e...
Magnetic field dependent electro-conductivity of the graphite doped magnetorheological plastomers.Soft Matter 11 , 6893-902, (2015)
In this work we reported a novel graphite doped conductive magnetorheological plastomer (GMRP) with magnetic field dependent electro-conductivity. The conductivity of the GMRPs increased by increasing...
LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate.Toxicol. Lett. 134(1-3) , 259-64, (2002)
To improve the biological monitoring method for 2,6- and 2,4-toluenediisocyanate (TDI) exposure, we developed a simple and rapid method for analysis of the corresponding urinary metabolites, 2,6- and ...