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Diprotin B

Names

[ CAS No. ]:
90614-49-6

[ Name ]:
Diprotin B

[Synonym ]:
L-valyl-L-prolyl-L-leucine
VAL-PRO-LEU
Diprotin B

Biological Activity

[Description]:

Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Chemical & Physical Properties

[ Density]:
1.157 g/cm3

[ Boiling Point ]:
575.9ºC at 760 mmHg

[ Molecular Formula ]:
C16H29N3O4

[ Molecular Weight ]:
327.41900

[ Flash Point ]:
302.1ºC

[ Exact Mass ]:
327.21600

[ PSA ]:
112.73000

[ LogP ]:
1.60530

[ Index of Refraction ]:
1.519

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OH3350000
CHEMICAL NAME :
L-Leucine, N-(1-L-valyl-L-prolyl)-
CAS REGISTRY NUMBER :
90614-49-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H29-N3-O4
MOLECULAR WEIGHT :
327.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,422,1984

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

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