2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine

Names

[ Name ]:
2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-6,7-dimethoxy-quinolin-4-amine

[Synonym ]:
4-amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)quinoline
UNII-F738MWY53L
Abanoquil

Biological Activity

[Description]:

Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

α1-adrenergic receptor

[In Vivo]

Abanoquil 在猴子模型体内注射时能够松弛收缩的组织条并诱导勃起反应[1]。

[References]

[1]. A Giraldi, et al. Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue. Int J Impot Res. 2000 Mar;12(S1):S37-S40.

[2]. T C Tham, et al. Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man. Br J Clin Pharmacol. 1992 Apr;33(4):405-9.

Chemical & Physical Properties

[ Density]:
1.246g/cm3

[ Boiling Point ]:
630.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₅N₃O₄

[ Molecular Weight ]:
395.45200

[ Flash Point ]:
335ºC

[ Exact Mass ]:
395.18500

[ PSA ]:
79.07000

[ LogP ]:
4.06030

Synthetic Route

Click to get detail synthetic route

Related Compounds

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