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Protamine sulfates

Names

[ CAS No. ]:
9009-65-8

[ Name ]:
Protamine sulfates

[Synonym ]:
H2SO4
EINECS 236-903-3
Oil of vitriol
MFCD00064589
UNII:0DE9724IHC
Sulfate, hydrogen
Sulfuric(VI) acid
Sulfuric acid
Sulphuric acid

Biological Activity

[Description]:

Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer[1][2][3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
Research Areas >> Metabolic Disease

[In Vitro]

Protamine sulfate has an inhibitory effect on thrombin in the conversion of fibrinogen to fibrin, and that this inhibition is concentration dependent, partial, and reversible[3]. Protamine sulfate is a 5-kDa cationic polypeptide derived from salmon sperm that can bind negatively charged unfractionated heparin (UFH). Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation[4].

[References]

[1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544.

[2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8.

[3]. R J Cobel-Geard, et al. Interaction of protamine sulfate with thrombin. Am J Hematol. 1983 May;14(3):227-33.

[4]. Fionnuala Ni Ainle, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65.

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
330.0±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C264H460N128O65S7

[ Molecular Weight ]:
6691.85629

[ Exact Mass ]:
6687.46695

[ LogP ]:
-1.03

[ Appearance of Characters ]:
amorphous powder | white

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.537

[ Storage condition ]:
+2C to +8C

[ Water Solubility ]:
H2O: 10 mg/mL | It is sparingly soluble in water.

Safety Information

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VO9470000

Related Compounds