Cytochrome C

Names

[ Name ]:
Cytochrome C

[Synonym ]:
Cytochromert
EINECS 232-700-9
myohematin
Cytor-est
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis[1-[[2-amino-3-(methylamino)-3-oxopropyl]thio]ethyl]-3,8,13,17-tetramethyl-, iron(2+) salt (1:1)
CYT-C
Iron(2+) (1Z,6Z,12Z,17Z)-4,9-bis(1-{[2-amino-3-(methylamino)-3-oxopropyl]sulfanyl}ethyl)-15,19-bis(2-carboxyethyl)-5,10,14,20-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1.1.1] tetracosa-1,3(24),4,6,8,10,12,14,16(22),17,19-undecaene-21,23-diide
Cytomac P
cytorest
MFCD00130890

Biological Activity

[Description]:

Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Metabolic Disease

[In Vitro]

哺乳动物 Cytochrome C 在健康状态下清除活性氧 (ROS)，在凋亡过程中与辅因子 p66Shc 产生 ROS，氧化心磷脂[1]。

[References]

[1]. Hüttemann M, et al. The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis. Mitochondrion. 2011 May;11(3):369-81.

Chemical & Physical Properties

[ Boiling Point ]:
1323.5ºC at 760 mmHg

[ Melting Point ]:
300ºC

[ Molecular Formula ]:
C₄₂H₅₂FeN₈O₆S₂

[ Molecular Weight ]:
884.887

[ Flash Point ]:
754.2ºC

[ Exact Mass ]:
884.280090

[ PSA ]:
286.03000

[ LogP ]:
3.85300

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 10 mg/mL, clear, dark red-brown | 100 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5365000

CHEMICAL NAME :: Cytochrome C

CAS REGISTRY NUMBER :: 9007-43-6

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 ug/plate

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;Xn: Harmful;

[ Risk Phrases ]:
36/37/38-20/21/22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HA5365000

[ HS Code ]:
3507909000

Customs

[ HS Code ]: 3507909000

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