Tween 60

Names

[ Name ]:
Tween 60

[Synonym ]:
D-Glucitol, 1,4-anhydro-2,3-bis-O-(2-hydroxyethyl)-6-O-(1-oxododecyl)-
MFCD01780110
1,4-Anhydro-6-O-dodecanoyl-2,3-bis-O-(2-hydroxyethyl)-D-glucitol
Polyoxyethylene sorbitan monostearate
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]thymidine
Polyethylene glycol sorbitan monostearate
polysorbate 60
Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-

Biological Activity

[Description]:

Polyoxyethylene Sorbitan Monostearate is an ester of the saturated fatty acid stearic acid (C18:0). Polyoxyethylene Sorbitan Monostearate can be used as an excipient, such as surfactant, emulsifier, solubilizer, wetting agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Lind ML, et al. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80. Eur J Pharm Sci. 2008 Oct 2;35(3):211-8.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.081

[ Boiling Point ]:
583.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₄₆O_6.(C₂H₄O)n

[ Flash Point ]:
190.4±23.6 °C

[ PSA ]:
133.14000

[ LogP ]:
8.09

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
100 g/L

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
WG2934000

[ HS Code ]:
34021300

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