Ethylparaben

Names

[ Name ]:
Ethylparaben

[Synonym ]:
4-Hydroxybenzoic acid, ethyl ester
Ethyl 4-hydroxybenzoate
Ethyl parasept
4-hydroxybenzoic acid ethyl ester
Benzoic acid, 4-hydroxy-, ethyl ester
ethyl p-hydroxybenzoate
EINECS 232-577-1
Nipagina A
Ethyl chemosept
Solbrol A
MFCD00081483
Ethyl p-oxybenzoate
ETHYL PARABEN
Ethylparaben

Biological Activity

[Description]:

Catalase is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors[1]. Free oxygen radical scavenger.

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Catalase, the enzyme that metabolizes H2O2 but also reacts with a multitude of other substrates. The active site of catalase contains an iron atom. Human catalase contains four identical subunits, each subunit containing four distinct domains and one prosthetic heme group. The four domains include: (1) a N-terminal arm which contains a distal histidine, an essential amino acid for the catalase reaction; (2) a β-barrel domain that contains eight β-barrels arranged in an antiparallel fashion with six α-helical insertions, conferring the hydrophobic core of the protein necessary for the tri-dimensional structure of the enzyme; (3) a connection domain which contains the tyrosine residue that binds the heme group; and finally (4) an α-helical domains, which is important for NADPH binding[1].

[References]

[1]. Glorieux C, et al. Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach. Biol Chem. 2017 Sep 26;398(10):1095-1108.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
297.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₀O₃

[ Molecular Weight ]:
166.174

[ Flash Point ]:
120.3±12.6 °C

[ Exact Mass ]:
166.062988

[ LogP ]:
2.40

[ Appearance of Characters ]:
suspension | deep brown

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
2-8°C

[ Stability ]:
Air and moisture sensitive. Incompatible with strong oxidizing agents. Refrigerate.

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US);type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
B

[ Risk Phrases ]:
10

[ Safety Phrases ]:
23-24/25-22

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
FI4378000

[ Hazard Class ]:
3.0

Articles

Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.

Nucleic Acids Res. 43(11) , 5524-36, (2015)

During the early steps of ribosome biogenesis in mammals, the two ribosomal subunits 40S and 60S are produced via splitting of the large 90S pre-ribosomal particle (90S) into pre-40S and pre-60S pre-r...

Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CP.

J. Bacteriol. 191(15) , 4996-5009, (2009)

Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative funct...

Spatial Control of Epsin-induced Clathrin Assembly by Membrane Curvature.

J. Biol. Chem. 290 , 14267-76, (2015)

Epsins belong to the family of highly conserved clathrin-associated sorting proteins that are indispensable for clathrin-mediated endocytosis, but their precise functions remain unclear. We have devel...