BR1

Names

[ Name ]:
BR1

[Synonym ]:
prl-3 inhibitor i
prl-3 inhibitor

Biological Activity

[Description]:

PRL-3 Inhibitor I is a potent PRL-3 inhibitor with an IC50 of 0.9 μM. PRL-3 Inhibitor I shows a reduced invasion in cell-based assay[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 0.9 μM (PRL-3)[1]

[In Vitro]

PRL-3 Inhibitor I reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay[1].

[References]

[1]. Ahn JH, et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorg Med Chem Lett. 2006;16(11):2996-2999.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₁Br₂NO₂S₂

[ Molecular Weight ]:
485.21300

[ Exact Mass ]:
482.86000

[ PSA ]:
95.72000

[ LogP ]:
5.60820

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H410

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.

Bioorg. Med. Chem. Lett. 16 , 2996-2999, (2006)

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most act...

Related Compounds

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