Rosamultin

Names

[ Name ]:
Rosamultin

[Synonym ]:
Tormentic acid glucosyl
Rosamutin
ursolazuroside 1

Biological Activity

[Description]:

Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. Rosamultin has inhibitory effects against HIV-1 protease[1]. Rosamultin has the potential for treating H2O2-induced oxidative stress injury through its antioxidant and antiapoptosis effects[2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

IC50: HIV-1 protease[1]

[In Vitro]

Rosamultin isolated from the root of R. rugosa inhibits HIV-1 protease by 53% at a concentration of 100 μM[1].

[References]

[1]. Zhang L, et al. Protective Effect of Rosamultin against H2O2-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes.Oxid Med Cell Longev. 2018 Jul 16;2018:8415610.

[2]. Park JC, et al. Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.J Med Food. 2005 Spring;8(1):107-9.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
741.5ºC at 760 mmHg

[ Molecular Formula ]:
C₃₆H₅₈O₁₀

[ Molecular Weight ]:
650.84000

[ Flash Point ]:
223.6ºC

[ Exact Mass ]:
650.40300

[ PSA ]:
177.14000

[ LogP ]:
2.43370

[ Index of Refraction ]:
1.604