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Polygalasaponin F

Names

[ CAS No. ]:
882664-74-6

[ Name ]:
Polygalasaponin F

[Synonym ]:
β-D-Xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]-β-D-glucopyranose
Polygalasaponin F
POLYGALASAPONIN F (REFERENCE GRADE)
3-O--D-galactopyranosylbayogenin 28-O-[-D-xylopyranosyl-(1->4)--L-rhamnopyranosyl-(1->2)--D-glucopyranosyl] ester
Polygalasaponin-F
β-D-Glucopyranose, O-β-D-xylopyranosyl-(1->4)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl]-
PolygalasaponinF

Biological Activity

[Description]:

Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway [1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Research Areas >> Inflammation/Immunology

[Target]

TLR4

PI3K

Akt

NF-κB


[References]

[1]. Yan WF , et al. The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res. 2015;17(6):662-70.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C53H86O23

[ Molecular Weight ]:
1091.236

[ Exact Mass ]:
1090.556030

[ PSA ]:
374.13000

[ LogP ]:
2.32

[ Index of Refraction ]:
1.640

Related Compounds