STING agonist C11

Names

[ Name ]:
STING agonist C11

[Synonym ]:
Benzeneacetamide, N-[(methylamino)carbonyl]-α-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-
N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide

Biological Activity

[Description]:

STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells; induces transcription and translation of interferon-dependent antiviral genes, induces canonical IRF3 phosphorylation and ISG transcription in a manner that requires STING but not MAVS or TRIF; potently blocks replication of multiple emerging Alphavirus types including Chikungunya, Ross River, Mayaro, and O'nyong'nyong viruses.

[References]

References 1. Gall B, et al. J Virol. 2017 Dec 20. pii: JVI.01913-17. View Related Products by Target STING

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₈N₄O₃S

[ Molecular Weight ]:
382.436

[ Exact Mass ]:
382.109955

[ LogP ]:
4.73

[ Index of Refraction ]:
1.650

Related Compounds

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