STING agonist C11
Names
[ CAS No. ]:
875863-22-2
[ Name ]:
STING agonist C11
[Synonym ]:
Benzeneacetamide, N-[(methylamino)carbonyl]-α-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-
N-(Methylcarbamoyl)-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-phenylacetamide
Biological Activity
[Description]:
STING agonist C11 is a novel cell-permeable STING agonist that activates IFN-dependent signaling processes and induces IFN secretion from human cells; induces transcription and translation of interferon-dependent antiviral genes, induces canonical IRF3 phosphorylation and ISG transcription in a manner that requires STING but not MAVS or TRIF; potently blocks replication of multiple emerging Alphavirus types including Chikungunya, Ross River, Mayaro, and O'nyong'nyong viruses.
[References]
References 1. Gall B, et al. J Virol. 2017 Dec 20. pii: JVI.01913-17. View Related Products by Target STING
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C19H18N4O3S
[ Molecular Weight ]:
382.436
[ Exact Mass ]:
382.109955
[ LogP ]:
4.73
[ Index of Refraction ]:
1.650