retronecine hydrochloride
Names
[ CAS No. ]:
875-22-9
[ Name ]:
retronecine hydrochloride
Chemical & Physical Properties
[ Density]:
1.29g/cm3
[ Boiling Point ]:
291.3ºC at 760 mmHg
[ Molecular Formula ]:
C8H14ClNO2
[ Molecular Weight ]:
191.65500
[ Flash Point ]:
161.4ºC
[ Exact Mass ]:
191.07100
[ PSA ]:
43.70000
[ LogP ]:
0.09380
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VH7350000
- CHEMICAL NAME :
- Retronecine hydrochloride
- CAS REGISTRY NUMBER :
- 875-22-9
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H13-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 191.68
- WISWESSER LINE NOTATION :
- T55 AN CUTJ D1Q FQ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Liver - other changes
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 185,842,1960
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 49,665,1972 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Spinal Cord - tumors
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 49,665,1972 *** REVIEWS *** TOXICOLOGY REVIEW CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976