Propargyl-PEG4-alcohol

Names

[ Name ]:
Propargyl-PEG4-alcohol

[Synonym ]:
15-hydroxy-4,7,10,13-tetraoxapentadec-1-yne
3,6,9,12-Tetraoxapentadec-14-yn-1-ol
2-{2-[2-(2-proponyloxy-ethoxy)-ethoxy]-ethoxy}-ethanol
2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethanol
propargyl-PEG5
tetraethylene glycol monopropargyl ether

Biological Activity

[Description]:

Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₀O₅

[ Molecular Weight ]:
232.27300

[ Exact Mass ]:
232.13100

[ PSA ]:
57.15000

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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