2',3'-Dideoxy-3'-fluoroadenosine

Names

[ Name ]:
2',3'-Dideoxy-3'-fluoroadenosine

[Synonym ]:
9-(3-Fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine
3'-Fluoro-2',3'-dideoxyadenosine
3'-
2',3'-Dideoxy-3'-fluoroadenosine
Adenosine, 2',3'-dideoxy-3'-fluoro-

Biological Activity

[Description]:

2′,3′-Dideoxy-3′-fluoroadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
541.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂FN₅O₂

[ Molecular Weight ]:
253.23

[ Flash Point ]:
281.2±32.9 °C

[ Exact Mass ]:
253.097504

[ PSA ]:
99.08000

[ LogP ]:
-0.20

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.796

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%