DRV1 (GPR32) agonist C2A

Names

[ Name ]:
DRV1 (GPR32) agonist C2A

[Synonym ]:
Benzamide, 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-
3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide

Biological Activity

[Description]:

DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.

[References]

References 1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₁₄F₂N₄O

[ Molecular Weight ]:
364.348

[ Exact Mass ]:
364.113556

[ LogP ]:
3.72

[ Index of Refraction ]:
1.654

Related Compounds

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